It used to be much, much more difficult than it is today, but your experiences will still vary according to what type of printer you have. The problem is drivers. There are still printers out there that have no working Linux driver (mostly old, non-Postscript-supporting, with no Mac drivers either). Some will work with a generic driver, but some features aren’t available. The more annoying case is the one where the manufacturer put out a driver once, many years ago, it doesn’t work properly with modern versions of CUPS, and they can’t be arsed to revise it.

But most printers these days will do basic one-sided 100%-size prints out of the box, and that’s all many people need.