I’m thinking I would go with either, “swing it, baby” or “right on, sister!”
So, like-
“Mr. Nartik, set course for Tau Alpha III. Warp six.”
“Course laid in, sir.”
“Right on, sister!”
This would be the 23rd or 24th century gender-neutral form of the word sister, obviously.
I’m not going to tell Captain Reno how to run their ship, but I really don’t think Dr. Culber should be at the helm.
Ha. Medical officer at the helm is really stretching the limits of the omnidisciplinary scienteist/doctor character.